|Present Work and Research|
Organosulfur Compounds: Kinetics and mechanism of the oxidation of organosulfur compounds (4-Methyl-3-thiosemicarbazide, N-Acetylthiourea, N-acetylcysteine and zincdiethyldithiocarbamate) in the presence of physiological oxidants (hydrogen-peroxide, Chlorous acid and bromous acid ).
Biologically-relevant reactions involving sulfur compounds include S-oxygenations, metabolic activation, cytoprotectivity action, and toxicity effects. There are no other groups of compounds that display such a wide range of biological activity. While the action and effects of organic sulfur compounds on human health is well-documented, the mechanisms by which these specific activities are expressed are unknown. Therefore it is imperative that compounds such as thiols and thioamines be studied.
My major research thrust is a mechanistic elucidation of biologically-relevant reactions of thiols, thioamides (especially thiocarbamides ), and sulfides. A careful and systematic study of this nature is long overdue.
Metal ions and reactive oxygen species: Presently, I am also involved in working with metal catalysis using Copper. Many studies have shown that metals such as iron, copper, chromium and vanadium undergo redox cycling and, under aerobic conditions, this often results in the production of toxic reactive oxygen species (ROS) such as hydrogen peroxide, hydroxyl and superoxide radicals.